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NCT07692217From ClinicalTrials.govRecruiting

TG-INSIGHT With Joint POCUS, Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies

Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies (TG-INSIGHT With Joint POCUS)

  • Hemophilia A
  • Factor VIII (FVIII)

At a glance

Phase
Phase not stated
Study type
Observational
Sponsor
University of Texas Southwestern Medical Center
Enrolment target
60
Started
22 July 2026
Main results due
May 2033
Study sites
1
Registry updated
29 September 2026

Can you take part?

  • Aged 6 months and over.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Participants with moderate or severe HA who are on prophylaxis with either weekly, biweekly, or every 4-weeks emicizumab or weekly efanesoctocog alfa for at least 2 months.
* \>6 months of age

Exclusion Criteria:

* Participants with active FVIII inhibitor (\>0.5 BU/mL)
* Presence of an additional bleeding disorder other than hemophilia A

What this study is about

In the sponsor’s own words, from the registry.

This is an observational research study to find out if there is a difference in the way children with moderate or severe hemophilia A, treated on two different types of factor replacement, form a clot and also evaluate if they develop tiny bleeds within the joint and subsequently early joint changes when receiving extended half-life factor VIII.

Study sites(1)

  • The University of Texas Southwestern Medical Center

    Dallas, Texas, United States

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07692217. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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TG-INSIGHT With Joint POCUS, Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement an | Trialion