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NCT07698652From ClinicalTrials.govRecruiting

Diaphragmatic and Box Breathing on Heart Rate Variability and Perceived Stress

Enhancing Physiological and Psychological Resilience: A Comparative Study of Diaphragmatic and Box Breathing in Physical Therapy Students.

  • Stress
  • Psychological Resilience
  • Healthy Students

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
Cairo University
Enrolment target
60
Started
20 September 2026
Main results due
30 December 2026
Study sites
1
Registry updated
28 September 2026

Can you take part?

  • Ages 18 years to 25 years.
  • Open to any sex.
  • Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Academic Status: Currently enrolled, full-time undergraduate Physical Therapy students
* Age Range: 18-25 years
* Health Status: Generally healthy individuals with no known chronic respiratory or cardiovascular diseases.
* Informed Consent: Ability and willingness to provide written informed consent and commit to the 4-week protocol (6 sessions/week).
* Stress Level: A baseline score on the Perceived Stress Scale (PSS) indicating at least moderate stress.

Exclusion Criteria:

* Pre-existing Breathing Expertise: Individuals with professional training in yoga (Pranayama), formal meditation, or advanced breath work that might bias the baseline results.
* Medical Conditions: Diagnosed respiratory conditions (e.g., Asthma, COPD).
* Cardiovascular issues (e.g., Arrhythmias, Hypertension).
* Clinical psychological disorders (e.g., Generalized Anxiety Disorder or Panic Disorder) that may require medication.
* Pharmacological Factors: Use of medications that influence the Autonomic Nervous System (e.g., Beta-blockers, antidepressants, or heavy use of stimulants/sedatives).
* Substance Use: Smokers/Vapers
* Excessive Caffeine "Participants consuming more than 400 mg of caffeine per day (equivalent to approximately 4 standard cups of brewed coffee) will be excluded.
* Recent Acute Illness: Any respiratory tract infection or fever within two weeks prior to the start of the study

What this study is about

In the sponsor’s own words, from the registry.

The goal of this clinical trial is to learn if diaphragmatic breathing and box breathing work to enhance resilience and manage stress in physical therapy students. It will also learn about their effects on overall physiological and psychological parameters. The main questions it aims to answer are:

Do these breathing techniques improve heart rate variability (HRV)?

How do these interventions affect participants' perceived stress levels, cognitive performance, and academic achievement?

Researchers will compare diaphragmatic breathing and box breathing to a control group to see if these non-invasive methods work to improve physiological adaptation and manage stress.

Participants will:

Be randomly assigned to practice diaphragmatic breathing, practice box breathing, or join a control group Have their heart rate variability (HRV) measured as a primary sign of physiological adaptation Complete assessments to evaluate their perceived stress, cognitive performance, and academic achievement

Study sites(1)

  • Faculty of Physical Therapy, Deraya University

    Minya, Minya Province, Egypt

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07698652. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Diaphragmatic and Box Breathing on Heart Rate Variability and Perceived Stress | Trialion