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NCT07710274From ClinicalTrials.govRecruiting

Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin Resistance Among Adults With Metabolic Syndrome: A Pilot Study (PRISM-I)

  • Metabolic Syndrome (MetS)

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
National University Health System, Singapore
Enrolment target
200
Started
17 September 2026
Main results due
June 2027
Study sites
1
Registry updated
25 September 2026

Can you take part?

  • Ages 21 years to 70 years.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

Participants will be included for if they are:

* (1) adults aged 21-70 years old;
* (2) willing and able to comply with using a CGM, smart ring, food logging app
* (3) able to provide written informed consent;
* (4) English-speaking and literate;
* (5) meet the inclusion criteria for metabolic syndrome and insulin resistance.
* The criteria for insulin resistance is HOMA-IR ≥ 2.5.
* The criteria for metabolic syndrome is to have high waist circumference (≥ 80cm for females and ≥ 90cm for males); and any two of the four below:
* (1) raised triglycerides: 1.7 mmol/L or on treatment;
* (2) reduced HDL cholesterol: \< 1.0 mmol/L (40 mg/dL) in men, \< 1.3 mmol/L (50 mg/dL) in women, or on treatment;
* (3) high blood pressure: 130/85 mmHg or on treatment; or
* (4) raised fasting glucose: 5.6 mmol/L (100 mg/dL) or previously diagnosed with T2DM

Exclusion Criteria:

Participants will be excluded from both phases if they are:

* (1) on insulin therapy;
* (2) are pregnant or lactating;
* (3) have a medical condition or are on a treatment that may interfere with study participation or metabolic assessments, as determined by the study investigators;
* (4) currently participating in other lifestyle modification programs.

What this study is about

In the sponsor’s own words, from the registry.

The primary objective of the Personalized Responses \& Integrated Systems for Metabolism (PRISM-I) pilot study is to assess the feasibility of conducting a definitive randomized controlled trial evaluating precision lifestyle interventions for improving insulin resistance in adults with metabolic syndrome.

Study sites(1)

  • National University of Singapore

    Singapore, Singapore

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07710274. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin R | Trialion