AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight
Efficacy and Safety of Once-daily Oral Zenagamtide in Participants With Obesity (AMAZE 9)
- Overweight
- Obesity
At a glance
- Phase
- Phase 3
- Study type
- Interventional
- Sponsor
- Novo Nordisk A/S
- Enrolment target
- 950
- Started
- 31 August 2026
- Main results due
- 27 June 2028
- Study sites
- 41
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Male or female (sex at birth). * Age 18 and older (both inclusive) at time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
What this study is about
In the sponsor’s own words, from the registry.
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Study sites(41)
Pinnacle Research Group LLC
Anniston, Alabama, United States
Recruiting
Univ of Alabama Birmingham
Birmingham, Alabama, United States
Recruiting
Chambliss Clinical Trials LLC
Montgomery, Alabama, United States
Recruiting
Providence Medical Foundation
Fullerton, California, United States
Recruiting
Torrance Clinical Research Institute, Inc.
Lomita, California, United States
Recruiting
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Recruiting
Univ of Colorado at Denver
Aurora, Colorado, United States
Recruiting
Brain Matters Research
Delray Beach, Florida, United States
Recruiting
Northeast Research Institute
Fleming Island, Florida, United States
Recruiting
Miguel Rebollar PA
Hialeah, Florida, United States
Recruiting
Jacksonville Ctr Clin Res
Jacksonville, Florida, United States
Recruiting
South Broward Research LLC
Miramar, Florida, United States
Recruiting
Clinical Neuroscience Solution
Orlando, Florida, United States
Recruiting
Florida Institute for Clinical Research, LLC
Orlando, Florida, United States
Recruiting
Oviedo Medical Research, LLC
Oviedo, Florida, United States
Recruiting
Hope Clin Res & Wellness
Conyers, Georgia, United States
Recruiting
East West Medical Research Institute_Honolulu
Honolulu, Hawaii, United States
Recruiting
Great Lakes Clinical Trials
Chicago, Illinois, United States
Recruiting
Clinical Investigation Spec Gurnee
Gurnee, Illinois, United States
Recruiting
Endeavor Health
Skokie, Illinois, United States
Recruiting
Evanston Premier Hlthcr Res
Skokie, Illinois, United States
Recruiting
Midwest Inst For Clin Res
Indianapolis, Indiana, United States
Not yet recruiting
Northern Pines Hlth Ctr, PC
Buckley, Michigan, United States
Recruiting
StudyMetrix Research LLC
City of Saint Peters, Missouri, United States
Recruiting
Palm Research Center Inc.
Las Vegas, Nevada, United States
Recruiting
Comprehensive Weight Ctrl Prog
New York, New York, United States
Recruiting
Medication Mgmnt, LLC_Grnsboro
Greensboro, North Carolina, United States
Recruiting
Accellacare of Raleigh
Raleigh, North Carolina, United States
Recruiting
Accellacare-Salisbury PMG Res
Salisbury, North Carolina, United States
Recruiting
Accellacare and KDCILM, LLC
Wilmington, North Carolina, United States
Recruiting
Lynn Institute of Norman
Norman, Oklahoma, United States
Recruiting
Clinical Res Collaborative
Cumberland, Rhode Island, United States
Recruiting
Medical Uni of SC Charleston
Charleston, South Carolina, United States
Recruiting
Coastal Carolina Research Ctr
North Charleston, South Carolina, United States
Recruiting
Hillcrest Clinical Research
Simpsonville, South Carolina, United States
Recruiting
Spartanburg Medical Research
Spartanburg, South Carolina, United States
Recruiting
Amarillo Medical Specialists
Amarillo, Texas, United States
Recruiting
North Texas Endocrine Center
Dallas, Texas, United States
Recruiting
Washington Cntr Weight Mgmt
Arlington, Virginia, United States
Not yet recruiting
Health Res of Hampton Roads
Newport News, Virginia, United States
Recruiting
National Clin Res Inc.
Richmond, Virginia, United States
Recruiting
Showing 41 of 41 sites. 39 of the 41 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07720271. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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