Evaluation of Levothyroxine Replacement Therapy After Total Thyroidectomy Using a Smart Wristband
Comparative Evaluation of the Effectiveness of Levothyroxine Replacement Therapy After Total Thyroidectomy Using Smart Wristband-Measured Nocturnal Heart Rate and Heart Rhythm Parameters Versus Thyroid Function Tests
- Total Thyroidectomy
- Hyperthyroidism
- Hypothyroidism
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Yeditepe University Hospital
- Enrolment target
- 40
- Started
- 22 July 2026
- Main results due
- 31 December 2026
- Study sites
- 1
- Registry updated
- 25 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age 18 years or older. * Undergoing total thyroidectomy at the Department of General Surgery, Yeditepe University Faculty of Medicine Hospital. * Initiation of postoperative levothyroxine replacement therapy as part of routine clinical care. * Willing and able to attend the routine 1-month postoperative thyroid function test follow-up. * Willing and able to wear the Xiaomi Smart Band 10 throughout the study period. * Able to provide written informed consent. Exclusion Criteria: * History of cardiac arrhythmia. * Current use of beta-blockers or other antiarrhythmic medications that may affect heart rate. * History of heart failure or advanced cardiovascular disease. * Diagnosed sleep disorders that may interfere with nighttime heart rate measurements. * Pregnancy. * Inability or unwillingness to wear the Xiaomi Smart Band 10 as required. * Missing clinical or laboratory data required for outcome assessment. * Refusal to participate or withdrawal of informed consent.
What this study is about
In the sponsor’s own words, from the registry.
The goal of this observational study is to determine whether nighttime heart rate and heart rhythm data collected by a smart wristband can identify under- or over-replacement with levothyroxine before the routine 1-month thyroid function tests in adults who have undergone total thyroidectomy.
After total thyroidectomy, patients usually start levothyroxine replacement therapy, and the dose is adjusted about 1 month later based on thyroid function tests. This study aims to determine whether changes in nighttime heart rate and heart rhythm can provide an earlier indication that the levothyroxine dose is too low or too high.
The main questions it aims to answer are:
Can nighttime heart rate and heart rhythm measured by a smart wristband identify under- or over-replacement with levothyroxine before routine thyroid function testing? How well do smart wristband measurements agree with thyroid function test results?
Participants will:
Wear a smart wristband after total thyroidectomy. Continue taking levothyroxine as prescribed by their physician. Undergo routine thyroid function testing approximately 1 month after surgery as part of standard clinical care.
Allow researchers to compare smart wristband measurements with thyroid function test results to evaluate whether wearable data can provide an earlier indication of inadequate or excessive levothyroxine replacement.
Study sites(1)
Yeditepe University Koşuyolu Hospital
Istanbul, Kadıköy, Turkey (Türkiye)
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07733375. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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