Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention

Inclusion Criteria:

* Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and/or parent/legal guardian report and confirmed by a structured interview
* screening positive for two or more risk factors targeted by the intervention
* Participants and parent(s)/legal guardian(s) agree to participate
* psychiatrically stable and have no major changes in antidepressant, stimulant, or antipsychotic medication in the past 4 weeks.

Exclusion Criteria:

* Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview
* Current or past antipsychotic medication use to specifically treat a psychotic disorder
* major medical and neurological conditions
* moderate to severe intellectual disabilities or mild intellectual disabilities but expected to have difficulty completing the study assessments;
* current drug or alcohol use that impacts functioning and study engagement;
* Not able to give assent, permission, or consent.
* Not able to undergo MRI.