NCT07759245From ClinicalTrials.govRecruiting

A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

A Phase 2, Multicenter, Randomized, Double-Blind, 52-week Study to Investigate the Efficacy and Safety of Brenipatide Compared With Placebo for the Treatment of Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

At a glance

Phase: Phase 2
Study type: Interventional
Sponsor: Eli Lilly and Company
Enrolment target: 606
Started: 7 August 2026
Main results due: May 2028
Study sites: 127
Registry updated: 25 September 2026

Can you take part?

Ages 40 years to 75 years.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Have a physician diagnosis of Chronic Obstructive Pulmonary Disease (COPD), at least 12 months prior to screening who meet the following criteria:

  * Current or former smokers with a smoking history of greater than or equal to (≥) 10 pack-years
  * Moderate-to-severe COPD (post-Bronchodilator (BD) Forced Expiratory Volume in 1 Second (FEV₁)/forced vital capacity (FVC) less than (\<) 70 percent (%)
  * Modified Medical Research Council Dyspnea Scale (mMRC-DS) grade ≥2
  * Exacerbation history of ≥2 moderate or ≥1 severe exacerbations within the year prior to inclusion.
  * Background double therapy \[long-acting β₂-agonists (LABA) + long-acting muscarinic antagonists (LAMA)\] or triple therapy \[inhaled corticosteroids (ICS) + LABA + LAMA)\] for 3 months prior to randomization with a stable dose of medication for ≥1 month prior to screening.

Exclusion Criteria:

* Have a known pre-existing, clinically important lung condition other than COPD.
* Have a current or recent acute, active infection before screening and up to randomization.

What this study is about

In the sponsor’s own words, from the registry.

The main purpose of this study is to assess if different dose levels of Brenipatide are safe and work the way they are intended to work in participants with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), when compared with placebo. The study will last approximately one year.

Study sites(127)

University of Alabama at Birmingham
Birmingham, Alabama, United States
Not yet recruiting
NewportNativeMD, Inc.
Newport Beach, California, United States
Recruiting
Institute of HealthCare Assessment d/b/a Apex Clinical Research
San Diego, California, United States
Recruiting
National Jewish Health Medical Center
Denver, Colorado, United States
Not yet recruiting
Millennium Medical Research - Miami
Miami, Florida, United States
Recruiting
Deluxe Health Center
Miami Lakes, Florida, United States
Recruiting
Florida Institute For Clinical Research, LLC
Orlando, Florida, United States
Recruiting
Axis Clinical Trials - Westchester
Westchester, Illinois, United States
Recruiting
Indiana University Health University Hospital
Indianapolis, Indiana, United States
Not yet recruiting
IU Health Ball Memorial Hospital, Inc.
Muncie, Indiana, United States
Recruiting
Brigham and Women's Hospital
Boston, Massachusetts, United States
Not yet recruiting
Revive Research Institute, Inc.
Southfield, Michigan, United States
Recruiting
Headlands Research-Twin Cities
Maplewood, Minnesota, United States
Recruiting
Clinical Research Associates of Central PA
DuBois, Pennsylvania, United States
Recruiting
Premier Pulmonary Critical Care and Sleep
Denison, Texas, United States
Not yet recruiting
Baylor College of Medicine Medical Center
Houston, Texas, United States
Not yet recruiting
Prime Clinical Research - Lewisville
Lewisville, Texas, United States
Recruiting
Paramount Clinical Research - Data Point Clinical Research
Kirkland, Washington, United States
Recruiting
Consultorios Médicos, Organización del Buen Ayre S.R.L.
Buenos Aires, Argentina
Recruiting
Centro Médico Viamonte
Buenos Aires, Argentina
Recruiting
Fundación Respirar
Buenos Aires, Argentina
Not yet recruiting
Fundacion Scherbovsky
Mendoza, Argentina
Recruiting
Instituto Médico Río Cuarto
Río Cuarto, Argentina
Recruiting
Centro de Salud e Investigaciones Médicas
Santa Rosa, Argentina
Recruiting
Private Practice - Dr. Robert Voves
Feldbach, Austria
Not yet recruiting
Klinikum Klagenfurt am Wörthersee
Klagenfurt, Austria
Not yet recruiting
Ordination für Lungenkrankheiten
Linz, Austria
Not yet recruiting
Klinik Floridsdorf
Vienna, Austria
Not yet recruiting
Dynamic Drug Advancement
Ajax, Canada
Not yet recruiting
Kelowna Health and Memory Centre
Kelowna, Canada
Not yet recruiting
Diex Recherche Inc. Division Sherbrooke Est
Sherbrooke, Canada
Not yet recruiting
Inspiration Research
Toronto, Canada
Not yet recruiting
C.I.C. Mauricie inc.
Trois-Rivières, Canada
Not yet recruiting
Dr. Syed Anees Medicine Professional Corporation
Windsor, Canada
Not yet recruiting
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T
Baotou, China
Not yet recruiting
China-Japan Friendship Hospital
Beijing, China
Not yet recruiting
Sichuan Provincial People's Hospital
Chengdu, China
Not yet recruiting
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
Not yet recruiting
Jiangyin People's Hospital
Jiangyin, China
Not yet recruiting
Jinan Central Hospital
Jinan, China
Not yet recruiting
Pingxiang People's Hospital
Pingxiang, China
Not yet recruiting
Shanghai General Hospital
Shanghai, China
Not yet recruiting
ShenZhen People's Hospital
Shenzhen, China
Not yet recruiting
Tianjin Medical University General Hospital
Tianjin, China
Not yet recruiting
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Not yet recruiting
The First People's Hospital of Xinxiang
Xinxiang, China
Not yet recruiting
MEDITRIAL s.r.o.
Jindichv Hradec, Czechia
Not yet recruiting
Private Practice - Dr. Ilona Pavlišová
Miroslav, Czechia
Not yet recruiting
CCR Ostrava s.r.o
Ostrava, Czechia
Not yet recruiting
Ordinace chorob plicních
Prague, Czechia
Not yet recruiting
Aalborg Universitetshospital, Syd
Aalborg, Denmark
Not yet recruiting
Aarhus Universitetshospital, Skejby
Aarhus, Denmark
Not yet recruiting
Bispebjerg Hospital
Copenhagen, Denmark
Not yet recruiting
Hvidovre Hospital
Hvidovre, Denmark
Not yet recruiting
Roskilde Sygehus
Roskilde, Denmark
Not yet recruiting
Vejle Sygehus
Vejle, Denmark
Not yet recruiting
CHRU de Brest
Brest, France
Not yet recruiting
Centre Hospitalier de Cholet
Cholet, France
Not yet recruiting
Henri Mondor Hospital
Créteil, France
Not yet recruiting
Chu Grenoble Alpes
La Tronche, France
Not yet recruiting

Showing 60 of 127 sites — filter to narrow it down. 20 of the 127 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07759245. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

Not the right study?

Answer three questions and see the studies recruiting near you, in plain language.

Find a study for me