NCT07776509From ClinicalTrials.govRecruiting

A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus

A Phase III Randomised, Double-Blind, Placebo-Controlled Multicentre Trial to Evaluate the Efficacy and Safety of AZD6234 as an Adjunct to Incretin-based Therapies in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity With or Without Type 2 Diabetes Mellitus (SELENE 3)

Obesity or Overweight
Weight-Related Comorbidity
With/Without Diabetes Mellitus, Type 2

At a glance

Phase: Phase 3
Study type: Interventional
Sponsor: AstraZeneca
Enrolment target: 500
Started: 24 August 2026
Main results due: 9 August 2028
Study sites: 96
Registry updated: 25 September 2026

Can you take part?

Aged 18 years and over.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Males \& females (inclusive of all gender identities) age ≥18 years
* BMI ≥ 30 kg/m2 OR BMI ≥ 27 kg/m2 with at least one of the following weight-related comorbidities (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease, heart failure, chronic kidney disease, metabolic dysfunction associated steatotic liver disease, osteoarthritis of the knee, or stress urinary incontinence
* For participants with T2DM only:

  * Diagnosed with T2DM ≥ 90 days prior to Screening
  * HbA1c value at Screening of ≥6.0% (42 mmol/mol) and ≤9.0% (75 mmol/mol) managed with diet and exercise alone or with a stable dose of any oral glycaemic-lowering agent and/or incretin-based medication
* Receiving a stable dose of incretin- based medications at a dose level that is sufficient for chronic weight management for at least 3 months prior to Screening and Randomisation.
* Stable body weight (≤ 3% body weight change) for at least 3 months prior to Randomisation
* History of at least one self-reported unsuccessful attempt to lose body weight in their lifetime

Exclusion Criteria:

* Obesity primarily caused by other endocrine disorders
* Type 1 diabetes mellitus
* Significant hepatobiliary disease and/or any of the following results at Screening:

  * ALT ≥ 3.0 × ULN
  * AST ≥ 3.0 × ULN
  * TBL \> 1.5 × ULN (except for cases of known Gilbert's Syndrome)
* Use of insulin therapy for T2DM within 3 months prior to screening

What this study is about

In the sponsor’s own words, from the registry.

The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment.

Study sites(96)

Research Site
Escondido, California, United States
Not yet recruiting
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Lincoln, California, United States
Recruiting
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Walnut Creek, California, United States
Not yet recruiting
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Jacksonville, Florida, United States
Not yet recruiting
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Jacksonville, Florida, United States
Not yet recruiting
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Stockbridge, Georgia, United States
Not yet recruiting
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Woodstock, Georgia, United States
Recruiting
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Champaign, Illinois, United States
Not yet recruiting
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Chicago, Illinois, United States
Not yet recruiting
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Beltsville, Maryland, United States
Not yet recruiting
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Oxon Hill, Maryland, United States
Not yet recruiting
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Kansas City, Missouri, United States
Not yet recruiting
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Las Vegas, Nevada, United States
Not yet recruiting
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Somerset, New Jersey, United States
Not yet recruiting
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Statesville, North Carolina, United States
Recruiting
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Fargo, North Dakota, United States
Recruiting
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Columbus, Ohio, United States
Not yet recruiting
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Portland, Oregon, United States
Not yet recruiting
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Smithfield, Pennsylvania, United States
Not yet recruiting
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Franklin, Tennessee, United States
Withdrawn
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Houston, Texas, United States
Recruiting
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Manassas, Virginia, United States
Not yet recruiting
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Renton, Washington, United States
Withdrawn
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Buenos Aires, Argentina
Not yet recruiting
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CABA, Argentina
Not yet recruiting
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Ciudad de Buenos Aires, Argentina
Recruiting
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Ramos Mejía, Argentina
Not yet recruiting
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Rosario, Argentina
Not yet recruiting
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San Nicolás, Argentina
Not yet recruiting
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Belo Horizonte, Brazil
Not yet recruiting
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Campinas, Brazil
Not yet recruiting
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Campinas, Brazil
Not yet recruiting
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São Paulo, Brazil
Not yet recruiting
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São Paulo, Brazil
Not yet recruiting
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São Paulo, Brazil
Not yet recruiting
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Calgary, Alberta, Canada
Not yet recruiting
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Calgary, Alberta, Canada
Recruiting
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Surrey, British Columbia, Canada
Recruiting
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Vancouver, British Columbia, Canada
Recruiting
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Guelph, Ontario, Canada
Recruiting
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Hamilton, Ontario, Canada
Recruiting
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Stouffville, Ontario, Canada
Recruiting
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Toronto, Ontario, Canada
Withdrawn
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Joliette, Quebec, Canada
Recruiting
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Montreal, Quebec, Canada
Recruiting
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Beijing, China
Not yet recruiting
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Changchun, China
Not yet recruiting
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Chengdu, China
Not yet recruiting
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Chengdu, China
Not yet recruiting
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Guangzhou, China
Not yet recruiting
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Huzhou, China
Not yet recruiting
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Nanjing, China
Not yet recruiting
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Nanjing, China
Not yet recruiting
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Ningbo, China
Not yet recruiting
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Aarhus N, Denmark
Not yet recruiting
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Gandrup, Denmark
Not yet recruiting
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Herlev, Denmark
Not yet recruiting
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Herlev, Denmark
Suspended
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Holbæk, Denmark
Not yet recruiting
Research Site
Hvidovre, Denmark
Not yet recruiting

Showing 60 of 96 sites — filter to narrow it down. 21 of the 96 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07776509. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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