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NCT07829263From ClinicalTrials.govRecruiting

Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder

  • Cocaine Use Disorder

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
Virginia Commonwealth University
Enrolment target
36
Started
October 2026
Main results due
December 2027
Study sites
1
Registry updated
28 September 2026

Can you take part?

  • Ages 18 years to 65 years.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria

* Between 18 and 65 years-of-age.
* Meet current DSM-5 criteria for Cocaine Use Disorder (CocUD), moderate or severe
* Professed interest in CocUD treatment or reducing cocaine use.
* Understand and comply with study procedures
* Positive urine result for cocaine metabolite in at least one screening visit.

Exclusion Criteria

* Current DSM-5 diagnosis of any non-cocaine substance use disorder (SUD) other than alcohol use disorder-mild or cannabis use disorder-mild
* Epilepsy or a history of multiple seizures
* Taking any medications known to reduce seizure threshold
* History of migraines, ringing in the ears, and/or a head injury that resulted in a diagnosis of concussion and/or loss of consciousness
* Current scalp condition (e.g. psoriasis) or head wound that has not completely healed
* Currently pregnant or hoping to become pregnant at any point during the study
* Significant current suicidal or homicidal ideation
* Metal plate in skull or other embedded metal fragments in body or other bodily metal
* Claustrophobia or other MRI contraindications
* Fitted with electrical implants such as pacemaker
* Present with clinically significant symptoms of acute cocaine or opioid withdrawal (these individuals would be rescheduled after resolution of acute withdrawal, if possible).

What this study is about

In the sponsor’s own words, from the registry.

Cocaine Use Disorder (CocUD) is a significant public health issue with increasing cocaine-related overdose mortality. Effective treatments for CocUD are highly needed. One understudied target for CocUD therapeutics is improving cognitive function (CF) in that key theories attribute development of CocUD and other substance use disorders (SUD) to impaired CF, such as decreased ability to inhibit behavior. Heavy cocaine users show impairments in attention, working memory, planning, and response inhibition, affecting as many as 30-80% of individuals with SUD. These cognitive deficits affect patient engagement and participation in SUD treatment, thus necessitating SUD programs assess and accommodate cognitive problems throughout treatment.

Study sites(1)

  • Virginia Commonwealth University

    Richmond, Virginia, United States

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07829263. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder | Trialion