Detection of Biomarkers for Prosthetic Infection Type - (DEBIT)
- Prosthetic Joint Infection (PJI)
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Portsmouth Hospitals NHS Trust
- Enrolment target
- 40
- Started
- 13 February 2026
- Main results due
- 31 October 2026
- Study sites
- 2
- Registry updated
- 24 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Male or Female, aged 18 years or above. * Due to undergo prosthetic revision surgery for any reason identified by the clinical team. * Participant is willing and able to give informed consent for participation in the study. * Pre-operative blood samples and at least 5 substantial peri-prosthetic tissue samples of a suitable size to be distributed between labs as outlined were successfully collected (note that it may not be possible to collect synovial fluid in all cases). Exclusion Criteria: * The participant has previously undergone any kind of revision surgery for their hip implant. * The participant has received any antibiotic treatment within the previous two weeks (excluding antibiotics at induction). * Participant lacking capacity to give informed consent. * Any other clinical reason the participant should not be included in the study- at the discretion of the clinical team.
What this study is about
In the sponsor’s own words, from the registry.
Prosthetic joint infection (PJI) is a significant cause of failure in hip and knee arthroplasty and is often difficult to diagnose using current methods. This study aims to identify novel biomarkers for early and accurate diagnosis of PJI using nanopore sequencing technology (Oxford Nanopore Technologies). By analysing microbial profiles and host immune responses in samples from patients undergoing revision surgery, the study will compare infected and non-infected cases. Biomarkers will be investigated in periprosthetic tissue as well as less invasive sample types, including synovial fluid and blood, with the goal of improving early diagnosis and guiding future treatment strategies.
Study sites(2)
Queen Alexandra Hospital
Portsmouth, United Kingdom
Recruiting
Southampton General Hospital
Southampton, United Kingdom
Not yet recruiting
Showing 2 of 2 sites. 1 of the 2 sites on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07838064. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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