Efficacy of Lycium Barbarum Polysaccharide in Dry Eye Disease Management
Efficacy of Lycium Barbarum Polysaccharide in Dry Eye Disease Management : A Pilot Study
- Dry Eye Syndromes
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- The Hong Kong Polytechnic University
- Enrolment target
- 30
- Started
- 14 September 2026
- Main results due
- 1 January 2027
- Study sites
- 1
- Registry updated
- 25 September 2026
Can you take part?
- Ages 18 years to 60 years.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age 18 to 60 years at enrollment. * Clinical diagnosis of dry eye disease, defined as OSDI-12 score \>=13 and at least one clinical sign of dry eye disease. * Habitual visual acuity 6/9 or better in both eyes. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Ocular infection within 3 months before enrollment or ocular disease other than dry eye disease. * History of ocular surgery, including refractive surgery. * Use of dry eye-related products, such as artificial tears, within 1 month before enrollment. * Contact lens wear within 1 month before enrollment. * Long-term use of medications known to affect dry eye symptoms. * Severe or unstable systemic disease. * Infectious disease, such as viral influenza. * Known allergy or hypersensitivity to Lycium barbarum polysaccharide. * Pregnant or breastfeeding. * Any condition that, in the investigator's judgment, makes the participant unsuitable for the study.
What this study is about
In the sponsor’s own words, from the registry.
The goal of this pilot clinical study is to learn if Lycium barbarum polysaccharide (LBP) supplementation helps manage dry eye disease in adults. It will also learn about the safety of LBP supplementation.
The main questions it aims to answer are:
1. Does LBP supplementation improve dry eye symptoms after 12 weeks? 2. Does LBP supplementation improve clinical signs of dry eye disease, such as tear film stability, tear production, and ocular surface staining?
Researchers will evaluate changes in dry eye symptoms and eye examination results before and after LBP supplementation.
Participants will:
1. Take LBP tablets by mouth twice daily for 12 weeks 2. Visit the clinic at baseline, 4 weeks, and 12 weeks for checkups and eye tests 3. Complete dry eye questionnaires and undergo clinical assessments of tear film, ocular surface health, and related eye measurements
Study sites(1)
The Hong Kong Polytechnic University, School of Optometry, Optometry Clinic
Hong Kong, Hong Kong, Hong Kong
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07842536. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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