Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems
Clinical Evaluation of a Stannous Fluoride Toothpaste Versus a 67% Bicarbonate Toothpaste and Colgate Cavity Protection Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems: a Six-month Clinical Study in Italy
- Plaque
- Dental Plaque
- Gingivitis
At a glance
- Phase
- Phase 3
- Study type
- Interventional
- Sponsor
- Colgate Palmolive
- Enrolment target
- 120
- Started
- 20 July 2026
- Main results due
- January 2027
- Study sites
- 1
- Registry updated
- 25 September 2026
Can you take part?
- Ages 18 years to 70 years.
- Open to any sex.
- Healthy volunteers can take part.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Subjects, ages 18-70, inclusive. * Availability for the six-month duration of the study. * Good general health. * Initial gingivitis index of at least 1.5 as determined by the use of the Modified Gingivitis Index. * Initial plaque index of at least 1.5 as determined by the use of the Modified Quigley-Hein Plaque Index. * Signed Informed Consent Form Exclusion Criteria: * Orthodontic bands. * Tumor(s) of the soft or hard tissues of the oral cavity. * Advanced periodontal disease (purulent exudate, tooth mobility), and/or * Extensive loss of periodontal attachment or alveolar bone. * Five or more carious lesions requiring immediate restorative treatment * Use of antibiotics any time during the one month prior to entry into the study. * Participation in any other clinical study or test panel within the one month prior to entry into the study. * Received a dental prophylaxis in the two weeks prior to your initial examination. * History of allergies to oral care/personal care consumer products or their ingredients. * Having taken any prescription medicines that might interfere with the study outcome. * If you with an existing medical condition which prohibits you from not eating or drinking for periods of up to 4 hours. * Self-reported pregnant or breast feeding an infant. * History of drug abuse
What this study is about
In the sponsor’s own words, from the registry.
Qualified subjects will be enrolled and randomized to either one of the three study groups described above based on their initial modified gingivitis and plaque scores. Subjects will be instructed to use the products according to the instructions provided. Subjects will return to the dental office for evaluation after three months and six months of product use. All subjects will be followed for adverse events throughout the study.
Study sites(1)
Clinica Odontoiatrica Montesani
Roma, Rome, Italy
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07842991. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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