Perioperative GFAP and Neurological Complications After Carotid Endarterectomy
Investigation of the Association Between Perioperative Glial Fibrillary Acidic Protein Levels and Postoperative Neurological Complications After Carotid Endarterectomy
- Carotid Stenosis
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Filiz Ata
- Enrolment target
- 90
- Started
- 15 December 2025
- Main results due
- 1 December 2026
- Study sites
- 1
- Registry updated
- 28 September 2026
Can you take part?
- Ages 35 years to 90 years.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age 35 to 90 years * Scheduled to undergo elective isolated carotid endarterectomy * Willing and able to provide informed consent and the required blood samples Exclusion Criteria: * Acute coronary syndrome within the previous 3 months * Carotid endarterectomy planned in combination with another surgical procedure * Atrial fibrillation * Known inflammatory disease * Hematologic disease * Refusal to provide preoperative consent or a blood sample * Stroke with residual neurological sequelae within the previous year * Multiple sclerosis, Alzheimer disease, Parkinson disease, or another pre-existing neurological disease
What this study is about
In the sponsor’s own words, from the registry.
This prospective, single-center observational study will evaluate whether blood levels of glial fibrillary acidic protein (GFAP), a protein associated with injury to supporting cells in the brain, are related to neurological complications after carotid endarterectomy. Adults aged 35 to 90 years undergoing elective isolated carotid endarterectomy will be enrolled. Serum GFAP will be measured before surgery and 24 hours after surgery. Investigators will record perioperative clinical information and postoperative neurological outcomes, including transient ischemic attack, stroke, delirium, and cognitive dysfunction. Approximately 90 participants are planned. The study will not assign any treatment or procedure.
Study sites(1)
University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital
Bursa, Bursa, Turkey (Türkiye)
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07843979. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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