Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation
- Fetal Growth Restriction (FGR)
- Preterm Birth
- Still Births
- Abruptio Placentae
- Rupture of Membranes; Premature
- Preeclampsia
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Makerere University
- Enrolment target
- 4,000
- Started
- 25 July 2022
- Main results due
- 31 October 2026
- Study sites
- 2
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Women only.
- Healthy volunteers can take part.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Viable singleton pregnancy at the time of the dating ultrasound scan * At less than 18 weeks of gestation by ultrasound scan * Nulliparous * Women who are indigenous Africans * Those 18 years and above * Consent to participate in the study by the participant Exclusion Criteria: \- Those who reside more 30km than from Kawempe Hospital or Mulago Hospital
What this study is about
In the sponsor’s own words, from the registry.
Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in sub-Saharan Africa. These conditions, known as the Great Obstetrical Syndromes, are thought to result from problems with the development of the placenta early in pregnancy. However, there is limited information from African populations to help identify women at risk or improve prevention and treatment.
This study will enroll 4,000 first-time pregnant women in Uganda before 18 weeks of pregnancy and follow them throughout pregnancy until delivery. Participants will attend routine study visits where information about their health, pregnancy, and social circumstances will be collected. Physical examinations, ultrasound scans, and blood samples will be obtained at several time points during pregnancy, and blood and placental samples will be collected at birth. Some samples will be analyzed during the study, while others will be stored for future research with appropriate ethical approval.
The study will examine which clinical, biological, and social factors are associated with pregnancy complications. Researchers will use statistical methods and artificial intelligence (AI) techniques to identify patterns that may help predict which women are at increased risk of developing these conditions.
The knowledge gained from this study may support the development of better screening tools and strategies for preventing pregnancy complications, improve maternal and newborn health outcomes in Uganda and other African settings, and establish a valuable biobank to support future maternal and newborn health research.
Study sites(2)
Mulago Specialised Women and Neonatal Hospital
Kampala, Uganda
Recruiting
Kawempe National Referral Hospital
Kampala, Uganda
Recruiting
Showing 2 of 2 sites. 2 of the 2 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07844876. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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