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NCT07845422From ClinicalTrials.govRecruiting

A Study of Music Therapy for Anxiety in People With Cancer

Virtual AI-Assisted Music Therapy for Anxiety Symptoms in People With Advanced Cancer (VIRTUOSO)

  • Cancer

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
Memorial Sloan Kettering Cancer Center
Enrolment target
240
Started
4 September 2026
Main results due
September 2029
Study sites
7
Registry updated
28 September 2026

Can you take part?

  • Aged 18 years and over.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Criteria:

* Patients must have a pathologically confirmed advanced cancer diagnosis: stage III or IV lung cancer; any stage pancreatic cancer, unresectable cholangiocarcinoma, unresectable liver cancer, unresectable ampullary or peri-ampullary cancer, or other stage IV gastrointestinal cancer; stage III or IV ovarian or fallopian tube cancers or other stage IV gynecologic cancer; stage IV breast cancer; stage III testicular cancer or any stage IV genitourinary cancer; stage IV sarcoma; stage IV melanoma; stage IV endocrine cancer; lymphoma, myeloma, or leukemia
* Currently receiving oncological treatment
* Age ≥ 18; English or Spanish-speaking
* Ambulatory as indicated by a Karnofsky performance score of 60 or higher
* Score of 8 or higher on the Hospital Anxiety and Depression Scale (HADS) anxiety subscale
* Anxiety symptoms lasting for at least 1 month
* Greater than 6-month expected survival as judged by the treating oncologist
* No diagnosis of bipolar disorder, schizophrenia, or substance abuse
* Score of 10 or higher on Blessed Orientation-Memory-Concentration indicative of dementia
* No prior receipt of music therapy within the past six months
* Not currently receiving any form of psychotherapy
* Concomitant Medications
* No initiation or change in scheduled anxiety medications (e.g., anxiolytics, sedatives, hypnotics, antidepressants) within the past 4 weeks
* Initiation or change in PRN anxiety medications are allowed within the past 4 weeks
* No plan to initiate or change scheduled anxiety medications during the study
* Initiation or change in PRN anxiety medications are allowed during the study
* Access to an internet-connected device
* Able to provide informed consent
* Willing to adhere to study procedures, including randomization, session attendance, and completion of assessments

What this study is about

In the sponsor’s own words, from the registry.

The researchers are doing this study to compare two different music-based treatment approaches and see if one may work better to reduce anxiety. The researchers will also study whether these music-based treatment approaches help people feel socially connected and change how they cope with anxiety, and whether these changes are linked to lower anxiety levels. Both approaches use music-based activities to treat anxiety. One of the approaches uses an artificial intelligence (AI)-powered song creation platform to write songs with a music therapist. The other approach involves music listening exercises and music-based discussions with research staff, during which you will learn about music culture and history.

Study sites(7)

  • Memorial Sloan Kettering Basking Ridge (All protocol activities)

    Basking Ridge, New Jersey, United States

    Recruiting

  • Memorial Sloan Kettering Monmouth (All protocol activities)

    Middletown, New Jersey, United States

    Recruiting

  • Memorial Sloan Kettering Bergen (All protocol activities)

    Montvale, New Jersey, United States

    Recruiting

  • Memorial Sloan Kettering Cancer Center Suffolk - Commack (All protocol activities)

    Commack, New York, United States

    Recruiting

  • Memorial Sloan Kettering Westchester (All protocol activities)

    Harrison, New York, United States

    Recruiting

  • Memorial Sloan Kettering Cancer Center (All protocol activites)

    New York, New York, United States

    Recruiting

  • Memorial Sloan Kettering Nassau (All protocol activities)

    Uniondale, New York, United States

    Recruiting

Showing 7 of 7 sites. 7 of the 7 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07845422. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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A Study of Music Therapy for Anxiety in People With Cancer | Trialion