NCT07846007From ClinicalTrials.govRecruiting

Effects of Excitatory and Inhibitory LIFUS of GPi in Parkinsonian Patients Without DBS

Parkinson Disease (PD)

At a glance

Phase: Phase not stated
Study type: Interventional
Sponsor: University Health Network, Toronto
Enrolment target: 15
Started: 14 February 2024
Main results due: December 2027
Study sites: 1
Registry updated: 29 September 2026

Can you take part?

Ages 18 years to 90 years.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* 18-90 years of age
* Confirmed diagnosis of Parkinson's disease
* Stable dopaminergic medication dose for a minimum of 4 weeks

Exclusion Criteria:

* History of stroke or seizure
* Comorbid dementia
* Scored below 22 on the Montreal Cognitive Assessment (MoCA)
* Has intracranial implant(s) or device(s)
* Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD)
* Has a previous surgical intervention to treat the movement disorder such as lesioning or a Deep Brain Stimulation system in place.
* Presence of metal implanted in body that is contraindicated in TMS/MRI/peripheral electrical stimulation
* Pregnancy
* Major depression/psychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study
* Is on antipsychotics, anti-depressants, marijuana, or other recreational drugs that affect the nervous system
* Major musculoskeletal or neuromuscular disease or disorder of the hands, wrists and limbs
* Severe Dyskinesia
* Major systemic illness or infection

What this study is about

In the sponsor’s own words, from the registry.

Low intensity focused ultrasound (LIFUS) is a novel non-invasive brain stimulation (NIBS) technique that permits stimulation with high spatial focality and can reach greater depth compared other methods. This study will look at the effects of two different LIFUS stimulations on task performance in patients with Parkinson's disease. The effects of real stimulation will also be compared to sham stimulation. The evaluations will include behavioral tasks on the computer, the Unified Parkinson's Disease Rating Scale (UPDRS) motor scoring, and finger accelerometry recordings. These will be done before the LIFUS simulations and repeated after. This is to evaluate the different mechanisms and efficacy of these stimulations on deep brain areas.

Study sites(1)

Toronto Western Hospital
Toronto, Ontario, Canada
Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07846007. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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