NCT07846163From ClinicalTrials.govRecruiting

Pain Assessment Through Integrated Neurophysiology and Multidimensional Profiling

Exploring Pain: An OPM-MEG, Biomechanical, and Biopsychosocial Analysis in Chronic Low Back Pain

Chronic Low-back Pain (cLBP)

At a glance

Phase: Phase not stated
Study type: Observational
Sponsor: Aristotle University Of Thessaloniki
Enrolment target: 60
Started: 7 September 2026
Main results due: December 2027
Study sites: 1
Registry updated: 29 September 2026

Can you take part?

Ages 18 years to 45 years.
Open to any sex.
Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria (Group of Chronic Low Back Pain Patients):

* 18-45 years old
* Non-specific low back pain
* Duration of pain \> 3 months
* Positive SLUMP test

Inclusion Criteria (Group of Healthy Control Participants):

* 18-45 years old
* Healthy/ free of pain

Exclusion Criteria (Common for both groups):

* History of spinal injury
* History of cancer
* Bone metabolic diseases
* Inflammatory conditions (spondyloarthritis or systemic inflammatory diseases)
* Spondylolistethis
* Presence of neurological deficits suggesting active nerve root compression/radiculopathy (pathological of tendon reflexes, sensitivity and muscle strength)
* Diagnosed neurodegenerative/neurological disorders or epilepsy
* Psychiatric disorders
* High irritability, according to Severity, Irritability, Nature, Stage, and Stability- SINSS pain assessment tool.
* Claustrophobia due to the measurement process inside the shielded room
* Electrical/electronic implants(e.g. pacemakers), metallic surgical materials (e.g. plates, stent) and dental and orthodontic metallic materials (e.g. braces).

What this study is about

In the sponsor’s own words, from the registry.

This observational case-control study aims to investigate the central neurophysiological mechanisms underlying non-specific chronic low back pain (CLBP) with neural mechanosensitivity, with wearable Optically Pumped Magnetometers Magnetoencephalography (OPM-MEG). The study evaluates brain activity dynamics at rest and during controlled movement-evoked pain. Additionally, it explores the relationship between cortical processing markers and multidimensional biopsychosocial profiles (including pain intensity, kinesiophobia, catastrophizing, sleep quality, and functional disability) and gait adaptaions in adults with CLBP aged 18 to 45 compared to healthy pain-free controls.

Study sites(1)

Laboratory of Medical Physics and Digital Innovation, AUTH
Thessaloniki, Central Macedonia, Greece
Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07846163. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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