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NCT07846618From ClinicalTrials.govRecruiting

Acute Mental Fatigue and Muscle Strength

Influence of Acute Mental Fatigue on Muscle Strength and Limb Symmetry in Healthy Adults

  • Mental Fatigue
  • Muscle Strength Dynamometer

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
Florida Institute for Human and Machine Cognition
Enrolment target
50
Started
23 September 2026
Main results due
31 December 2027
Study sites
1
Registry updated
29 September 2026

Can you take part?

  • Ages 18 years to 39 years.
  • Open to any sex.
  • Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

1. Age 18-39 years
2. Able to produce maximal force against Biodex protocol
3. Able to perform required lower extremity movements through range of motion necessary for Biodex protocol
4. No known cognitive impairment
5. Sufficient musculoskeletal health to complete the tasks

Exclusion Criteria:

1. History of a neurological disorder, disease, or cognitive impairment that may affect cognition, motor control, reaction time, or force production
2. History of musculoskeletal injury affecting the lower extremities within the past 6 months
3. History of lower extremity surgery affecting force production of the hip, knee, or ankle
4. Color-vision impairment
5. Significant visual or hearing impairment
6. History of migraine headaches
7. Current significant sleep disturbances or sleep deprivation
8. Head injury that may affect cognitive function
9. Medical condition affecting ability to produce maximal force safely
10. Allergy to adhesive tape, parabens, or propylene glycol
11. Scalp lacerations, open wounds, or sutures on the scalp
12. Cranial surgery or skull defects
13. History of unexplained dizziness or fainting in the past 6 months
14. Individuals who are pregnant, prisoners, or not yet adults
15. Inability to communicate with investigators
16. Inability to provide written informed consent

What this study is about

In the sponsor’s own words, from the registry.

This study will investigate the acute effects of mental fatigue on lower-extremity muscle strength and limb symmetry in healthy young adults. Participants will complete lower-extremity strength testing before and after a standardized computer-based mental fatigue protocol involving tasks of attention, reaction time, concentration, and working memory. Muscle strength and limb symmetry will be assessed using isokinetic dynamometry, with muscle activity measured using surface electromyography. Participants will also complete subjective measures of mental fatigue, sleepiness, mental effort, and perceived physical exertion. Heart rate will be monitored throughout the study, and brain activity may be assessed during cognitive tasks. The study will determine whether acute mental fatigue is associated with changes in muscle strength, limb symmetry, and neuromuscular performance.

Study sites(1)

  • Florida Institute for Human and Machine Cognition

    Pensacola, Florida, United States

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07846618. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Acute Mental Fatigue and Muscle Strength | Trialion