Impact of Entropy Monitoring on Anesthetic Consumption and Recovery After Laparoscopic Cholecystectomy
Effect of Entropy Monitoring on Sevoflurane Consumption and Recovery From General Anesthesia in Patients Undergoing Laparoscopic Cholecystectomy
- Entropy Device and How Will Muscle Relaxants Affect it
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- KRL Hospital, Islamabad
- Enrolment target
- 120
- Started
- 1 July 2026
- Main results due
- October 2026
- Study sites
- 1
- Registry updated
- 29 September 2026
Can you take part?
- Ages 18 years to 60 years.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * ASA I or II * Elective laparoscopic cholecystectomy under GA Exclusion Criteria: * Emergency cholecystectomy * Co Morbid (Hypertension, Diabetes Mellitus, Ischemic Heart Disease, Chronic Kidney Disease, Asthma, Stroke) * Known allergy or contraindication to sevoflurane or study drugs * Addictions such as chronic use of sedatives, hypnotics or alcohol abuse on medical records * BMI of 30 or greater (Obese patients tend to have delated recovery from general anesthesia) * Pregnancy
What this study is about
In the sponsor’s own words, from the registry.
The goal of this clinical trial is to learn if brainwave-guided anesthesia (entropy monitoring) can reduce anesthetic drug consumption and speed up recovery time in adult patients undergoing elective laparoscopic cholecystectomy surgery under general anesthesia.
The main questions it aims to answer are:
* Does entropy monitoring significantly decrease the mean consumption rate of sevoflurane gas (in mL/hr) compared to traditional clinical monitoring during surgery? * Does entropy monitoring significantly reduce the mean recovery time (in minutes to open eyes on verbal command) after discontinuing anesthesia? Researchers will compare patients whose anesthesia depth is guided by real-time entropy monitoring (brainwave and facial muscle sensors) to patients whose anesthesia is guided by standard clinical signs (heart rate and blood pressure) to see if using entropy sensors reduces total anesthetic gas use and enables faster patient recovery.
Participants will:
* Receive routine pre-medication and general anesthesia induction for elective laparoscopic cholecystectomy. * Have continuous monitoring during surgery using either entropy brain/muscle sensors (Group A) or standard clinical vital signs (Group B) to guide the delivery of sevoflurane gas. * Have their total sevoflurane gas consumption rate automatically recorded at the end of surgery. * Be assessed after surgery for recovery time, measured in minutes from the time sevoflurane is turned off until they open their eyes upon verbal command.
Study sites(1)
KRL Hospital Islamabad
Islamabad, Pakistan
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07847788. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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